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Other things do not have the science yet

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The right dose depends on the indication, the patients weight and health history, and the prescribing providers clinical judgment

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it is a separate question from whether any given ingredient produces a specific health outcome, which is where honesty about the evidence matters

The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)